Protein Name
MAP kinase-interacting serine/threonine-protein kinase 2
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
51875
Protein Length
465
Protein Domain
3D Structure
(PDB ID : 6ck3)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Isoform 2: Nucleus,PML body;Isoform 1: Cytoplasm;
Function
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.
Gene Ontology
GO:0005737; GO:0016604; GO:0005654; GO:0005634; GO:0016605; GO:0005524; GO:0009931; GO:0005516; GO:0004683; GO:0046872; GO:0004674; GO:0007166; GO:0071243; GO:0097192; GO:0030097; GO:0035556; GO:0018105; GO:0046777; GO:0006468; GO:0006417