Gene
Synonyms
CAMKA KIAA0968
Protein Name
Calcium/calmodulin-dependent protein kinase type II subunit alpha
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
54088
Protein Length
478
Protein Domain
3D Structure
(PDB ID : 3soa)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cell junction,Synapse,Cell junction,Synapse,Postsynaptic cell membrane,Postsynaptic density,Cell projection,Dendritic spine,Cell projection,Dendrite;
Function
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378).
Gene Ontology
GO:0005954; GO:0030054; GO:0005737; GO:0005829; GO:0043197; GO:0030666; GO:0005739; GO:0043005; GO:0005654; GO:0005634; GO:0005886; GO:0014069; GO:0045211; GO:0098685; GO:0005524; GO:0009931; GO:0005516; GO:0004683; GO:0035254; GO:0042802; GO:0016301; GO:0046872; GO:0042803; GO:0004674; GO:0005088; GO:0038166; GO:0006816; GO:0048813; GO:0060996; GO:0000082; GO:0060333; GO:0000165; GO:0018105; GO:1990443; GO:0051928; GO:0010666; GO:0051092; GO:0046777; GO:0006468; GO:1902108; GO:2001222; GO:0048168; GO:0046928; GO:0099148; GO:0002931; GO:0007223