Protein Name
Ryanodine receptor 2
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
564819
Protein Length
4966
Protein Domain
3D Structure
(PDB ID : 2mc2)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Sarcoplasmic reticulum membrane,Membrane,Sarcoplasmic reticulum;
Function
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.
Gene Ontology
GO:0031672; GO:0034704; GO:0005737; GO:0030659; GO:0005783; GO:0031234; GO:0016021; GO:0016020; GO:0043005; GO:0005635; GO:0005886; GO:0032991; GO:0042383; GO:0030017; GO:0016529; GO:0033017; GO:0005790; GO:0030018; GO:0005262; GO:0005509; GO:0048763; GO:0015278; GO:0005516; GO:0019899; GO:0042802; GO:0097159; GO:0034236; GO:0034237; GO:0019901; GO:0043621; GO:0005219; GO:0097110; GO:0043924; GO:0030509; GO:0070588; GO:0006816; GO:0060402; GO:0019722; GO:0035584; GO:0060070; GO:0060048; GO:0003300; GO:0006874; GO:0071313; GO:0071872; GO:0060401; GO:0005513; GO:0003143; GO:0072599; GO:0034220; GO:0003220; GO:0071421; GO:0051481; GO:1901896; GO:0010460; GO:0051284; GO:0098735; GO:0086029; GO:0098910; GO:0098904; GO:0055117; GO:0010882; GO:0010881; GO:0051480; GO:0002027; GO:0098907; GO:0098911; GO:0051209; GO:0014808; GO:0031000; GO:0051592; GO:0001666; GO:0032026; GO:0014850; GO:0035994; GO:0051775; GO:0070296; GO:0097050; GO:0086005