EEF2K | Eukaryotic elongation factor 2 kinase
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
EEF2K
Synonyms
-
Protein Name
Eukaryotic elongation factor 2 kinase
UniProt ID
O00418 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000263026
NCBI Gene ID
29904
Molecular Weight
82144
Protein Length
725
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 5j8h)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.11.20; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
[translation elongation factor 2] + ATP = [translation elongation factor 2]-phosphate + ADP + H(+)
Localization
Function
Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
Gene Ontology
GO:0005737; GO:0005829; GO:0043197; GO:0014069; GO:0005524; GO:0005509; GO:0005516; GO:0004686; GO:0004672; GO:0008135; GO:0071454; GO:1990416; GO:0071277; GO:0071320; GO:0032869; GO:0043066; GO:0061003; GO:0045807; GO:0051965; GO:0046777; GO:0031952; GO:0002931; GO:1990637; GO:0006414
 
Gene Ontology