Help Instruction
- Double clicking on the substrate will redirect to the uniprot entry.
- Clicking in the block having the substrate will zoom into its phophosites
- Clicking the center of the circle will lead to zooming out.
- Clicking on the phosphosite will render the phosphosite in its 3D structure (if structure information/mapping is available).
- The color of every substrate has ben kept different in the Sunburst diagram for visual clarity.
- Clicking in the top right corner on the camara icon will download the image.
| Gene Name | Organism | P-Site | Sequence(+/-7) | Conservation | Disorder | Curator Assessment | Reliability | Evidence Class | Evidence Logic | PubMed | Phospho-ELM | PhosphoSite-Plus |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAPKAPK2 (O00418) | Homo sapiens | S377 | PPLLRPLSENSGDEN | 0.736 | 0.8565 | TP | certain | experimental | 135 | 133 | 73 | 55 | | 12171600 | Non high throughput (12171600) |
|
| PRKAA1 (O00418) | Homo sapiens | S398 | DSLPSSPSSATPHSQ | 0.546 | 0.7163 | TP | certain | experimental | 72 | 73 | 55 | 214 | 8 | 107 | | 14709557 | - |
|
| MAPKAPK3* (O00418) | Homo sapiens | S377 | PPLLRPLSENSGDEN | 0.736 | 0.8565 | TP | likely | experimental | 135 | 133 | 73 | | 12171600 | - | - |
| MAPKAPK5* (O00418) | Homo sapiens | S377 | PPLLRPLSENSGDEN | 0.736 | 0.8565 | TP | likely | experimental | 135 | 133 | 73 | | 12171600 | - | - |
| PRKAA1 (O00418) | Homo sapiens | S366 | SPQVRTLSGSRPPLL | 0.742 | 0.6227 | - | - | - | - | - | - | - |
| PRKAA1 (O00418) | Homo sapiens | S78 | SSGSPANSFHFKEAW | 0.374 | 0.3667 | - | - | - | - | - | - | - |
| PRKAA2 (O00418) | Homo sapiens | S398 | DSLPSSPSSATPHSQ | 0.546 | 0.7163 | - | - | - | - | - | - |
|
| PRKAA2 (O00418) | Homo sapiens | S366 | SPQVRTLSGSRPPLL | 0.742 | 0.6227 | - | - | - | - | - | - | - |
| PRKAA2 (O00418) | Homo sapiens | S78 | SSGSPANSFHFKEAW | 0.374 | 0.3667 | - | - | - | - | - | - | - |
| RPS6KA1 (O00418) | Homo sapiens | S366 | SPQVRTLSGSRPPLL | 0.742 | 0.6227 | - | - | - | - | - | - |
|
Help Instructions
- Hovering on the "*" in "Kinase Gene Name" column will display the text if there is a note by the annotator for the given site.
- The column having "Sequence" motif represents phosphosite and its neighbouring 7 residues (upstream and downstream).
- The score in "Conservation" column varies from 0 to 1; Higher the score more conserved is the site.
- The score in "Disorder" column varies from 0 to 1; Score higher than 0.4 suggests disorder.
- In the "Curator Assessment" column, TP refers to True Positive; FP refers to False Positive; and U refers to unknown if the annoatator cannot decide the status based on available information.
- Hovering on the number in the "Evidence Logic" column will show the name of method used to characterize/infer the phosphosite (for more details plase follow the link)