CaMKinet | Result

Gene

MDM4

Synonyms

MDMX

Protein Name

Protein Mdm4

UniProt ID

O15151 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000356150

NCBI Gene ID

4194

Molecular Weight

54864

Protein Length

490

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2cr8)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Nucleus;

Function

Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.

Gene Ontology

GO:0005654; GO:0005634; GO:0019899; GO:0061630; GO:0008270; GO:0008283; GO:0071456; GO:0030330; GO:0006977; GO:0045023; GO:0043066; GO:0071157; GO:0008285; GO:0042177; GO:0000122; GO:0016579; GO:0050821; GO:0065003; GO:1901796