KRT18 | Keratin, type I cytoskeletal 18
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer
Gene
KRT18
Synonyms
CYK18
Protein Name
Keratin, type I cytoskeletal 18
UniProt ID
P05783 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000373487
NCBI Gene ID
3875
Molecular Weight
48058
Protein Length
430
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Perinuclear region,Nucleus,Nucleolus;
Function
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Gene Ontology
GO:0071944; GO:0005913; GO:0034451; GO:0005737; GO:0005829; GO:0070062; GO:0005882; GO:0045095; GO:0005815; GO:0005730; GO:0048471; GO:0098641; GO:0003723; GO:0097110; GO:0005198; GO:0009653; GO:0007049; GO:0070268; GO:0097191; GO:0043000; GO:0097284; GO:0045104; GO:0031424; GO:0043066; GO:0033209; GO:0016032
 
Gene Ontology