Gene
Synonyms
EIF4EL1 EIF4F
Protein Name
Eukaryotic translation initiation factor 4E
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
25097
Protein Length
217
Protein Domain
3D Structure
(PDB ID : 1ipb)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,P-body,Cytoplasm;
Function
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
Gene Ontology
GO:0033391; GO:0005737; GO:0036464; GO:0010494; GO:0005829; GO:0016281; GO:0070062; GO:0098978; GO:0005845; GO:0000932; GO:0048471; GO:0099524; GO:0016442; GO:0019899; GO:0031370; GO:0070491; GO:0000340; GO:0003723; GO:0000339; GO:0003743; GO:0045182; GO:0001662; GO:0071549; GO:0000082; GO:0030324; GO:0006406; GO:0045665; GO:0017148; GO:0045931; GO:0006417; GO:0099578; GO:0006405; GO:0019827; GO:0006413; GO:0016032