CaMKinet | Result

EIF4E | Eukaryotic translation initiation factor 4E

Help Instruction

Double clicking on the substrate will redirect to the uniprot entry.
Clicking in the block having the substrate will zoom into its phophosites
Clicking the center of the circle will lead to zooming out.
Clicking on the phosphosite will render the phosphosite in its 3D structure (if structure information/mapping is available).
The color of every substrate has ben kept different in the Sunburst diagram for visual clarity.
Clicking in the top right corner on the camara icon will download the image.

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MKNK2* (P06730)	Homo sapiens	S209	DTATKSGSTTKNRFV	0.815	0.4507	TP	certain	experimental	72 \| 137 \| 133 \| 147 \| 73 \|	11154262	-	-
MKNK1* (P06730)	Homo sapiens	S209	DTATKSGSTTKNRFV	0.815	0.4507	TP	certain	experimental	72 \| 137 \| 133 \| 147 \| 73 \|	11154262	-	-
MKNK1 (P06730)	Homo sapiens	S209	DTATKSGSTTKNRFV	0.815	0.4507	-	-	-	-	-	-	In vivo

Help Instructions

Hovering on the "*" in "Kinase Gene Name" column will display the text if there is a note by the annotator for the given site.
The column having "Sequence" motif represents phosphosite and its neighbouring 7 residues (upstream and downstream).
The score in "Conservation" column varies from 0 to 1; Higher the score more conserved is the site.
The score in "Disorder" column varies from 0 to 1; Score higher than 0.4 suggests disorder.
In the "Curator Assessment" column, TP refers to True Positive; FP refers to False Positive; and U refers to unknown if the annoatator cannot decide the status based on available information.
Hovering on the number in the "Evidence Logic" column will show the name of method used to characterize/infer the phosphosite (for more details plase follow the link)