Protein Name
Gap junction alpha-1 protein
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
43031
Protein Length
382
Protein Domain
3D Structure
(PDB ID : 1r5s)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cell membrane,Cell junction,Gap junction,Endoplasmic reticulum;
Function
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization (PubMed:15181016). Plays an essential role in gap junction communication in the ventricles (By similarity).
Gene Ontology
GO:0016324; GO:0005922; GO:0043292; GO:0005737; GO:0005829; GO:0005769; GO:0005789; GO:0005768; GO:0005916; GO:0005921; GO:0005794; GO:0000139; GO:0030660; GO:0005887; GO:0005882; GO:0005770; GO:0016328; GO:0005764; GO:0016020; GO:0045121; GO:0005741; GO:0005771; GO:0005886; GO:0032991; GO:0048487; GO:0071253; GO:0097718; GO:0005243; GO:0055077; GO:0030165; GO:0019904; GO:1990782; GO:0097110; GO:0017124; GO:0005102; GO:0007512; GO:0006915; GO:0015867; GO:0003294; GO:0048514; GO:0060348; GO:0046849; GO:0061337; GO:0007154; GO:0010643; GO:0010644; GO:0007267; GO:0071260; GO:0071374; GO:0071467; GO:0002544; GO:0046697; GO:0042733; GO:0003158; GO:1905867; GO:0002070; GO:0016264; GO:0007507; GO:0001947; GO:0001701; GO:0002088; GO:0008584; GO:0099111; GO:0060156; GO:0060044; GO:0030308; GO:0008285; GO:2000279; GO:0001937; GO:0010629; GO:0061045; GO:0001764; GO:0048812; GO:0001649; GO:2000987; GO:0097755; GO:0010652; GO:0120162; GO:0007204; GO:0010628; GO:0003104; GO:0032024; GO:0045669; GO:0045732; GO:0045844; GO:0045907; GO:0051259; GO:0060371; GO:2000810; GO:0030500; GO:0046850; GO:0051924; GO:0022898; GO:0060373; GO:0060307; GO:0032355; GO:0034405; GO:0009749; GO:0002931; GO:0032496; GO:0043434; GO:0009268; GO:0032526; GO:0043403; GO:0007283; GO:0042098; GO:0055085; GO:0010232