CaMKinet | Result

Gene

CHRM2

Synonyms

Protein Name

Muscarinic acetylcholine receptor M2

UniProt ID

P08172 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000319984

NCBI Gene ID

1129

Molecular Weight

51715

Protein Length

466

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1lub)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cell membrane,Cell junction,Synapse,Postsynaptic cell membrane;

Function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.

Gene Ontology

GO:0032279; GO:0043679; GO:0030054; GO:0098981; GO:0030665; GO:0030425; GO:0098978; GO:0016021; GO:0005887; GO:0099055; GO:0099056; GO:0043025; GO:0005886; GO:0032280; GO:1990763; GO:0016907; GO:0004930; GO:0004993; GO:0030594; GO:0007197; GO:0007188; GO:0007268; GO:0007213; GO:0007186; GO:0007187; GO:0061024; GO:0007399; GO:0007207; GO:0008016; GO:0006940; GO:2000300; GO:0009615