MAPT | Microtubule-associated protein tau
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
MAPT
Synonyms
MAPTL MTBT1 TAU
Protein Name
Microtubule-associated protein tau
UniProt ID
P10636 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000262410
NCBI Gene ID
4137
Molecular Weight
78928
Protein Length
758
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1i8h)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Cytosol,Cell membrane,Cytoplasm,Cytoskeleton,Cell projection,Axon,Cytoplasm,Cell projection,Dendrite;
Function
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Gene Ontology
GO:0030673; GO:0030424; GO:1904115; GO:0044297; GO:0005737; GO:0036464; GO:0005829; GO:0030425; GO:0043197; GO:0005576; GO:0097386; GO:0030426; GO:0005622; GO:0044304; GO:0045121; GO:0005874; GO:0015630; GO:0005739; GO:0097418; GO:0043005; GO:0043025; GO:0034399; GO:0016607; GO:0005634; GO:0005886; GO:0036477; GO:0045298; GO:0003779; GO:0034185; GO:0003680; GO:0051087; GO:0003677; GO:0003690; GO:0034452; GO:0019899; GO:0099077; GO:0051879; GO:0042802; GO:0071813; GO:0008017; GO:0099609; GO:0035091; GO:1902936; GO:0030674; GO:0042803; GO:0019901; GO:0051721; GO:0048018; GO:0003723; GO:0043565; GO:0017124; GO:0003697; GO:0006919; GO:1990000; GO:0048143; GO:0061564; GO:0098930; GO:0019896; GO:0007267; GO:1990416; GO:0034605; GO:1990090; GO:0034614; GO:0021954; GO:0031122; GO:0048699; GO:0006475; GO:0048312; GO:0007611; GO:0007613; GO:0001774; GO:0000226; GO:0046785; GO:1903748; GO:0010629; GO:0033673; GO:0090258; GO:0010917; GO:1904428; GO:1902988; GO:0031175; GO:0072386; GO:0045773; GO:1903829; GO:1905689; GO:0031116; GO:1901216; GO:1902474; GO:0032930; GO:0051259; GO:0051260; GO:0010506; GO:0050848; GO:1900034; GO:0033044; GO:1900452; GO:0070507; GO:0031113; GO:0031110; GO:0090140; GO:2001020; GO:0048167; GO:0010288; GO:0016072; GO:0034063; GO:0097435; GO:0007416; GO:0050808
 
Gene Ontology