Protein Name
Calcium/calmodulin-dependent protein kinase type II subunit alpha
UniProt ID
Ensembl Gene ID
-
NCBI Gene ID
Molecular Weight
54115
Protein Length
478
Protein Domain
3D Structure
(PDB ID : 1cdm)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cell junction,Synapse,Cell junction,Synapse,Postsynaptic cell membrane,Postsynaptic density,Cell projection,Dendritic spine,Cell projection,Dendrite;
Function
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (PubMed:15312654). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity).
Gene Ontology
GO:0030424; GO:0005954; GO:0030054; GO:0005737; GO:0005829; GO:0030425; GO:0032839; GO:0043197; GO:0099573; GO:0098978; GO:0016020; GO:0005739; GO:0043005; GO:0043025; GO:0005634; GO:0099524; GO:0014069; GO:0099634; GO:0099523; GO:0005524; GO:0005516; GO:0004683; GO:0035254; GO:0032794; GO:0046872; GO:0004674; GO:0006816; GO:0099004; GO:0060996; GO:0000082; GO:0035235; GO:0098989; GO:0018105; GO:1990443; GO:0051928; GO:0010666; GO:0098970; GO:0046777; GO:0006468; GO:1902108; GO:2001222; GO:0048168; GO:0098696; GO:0046928; GO:1903076; GO:0002931