ATF4 | Cyclic AMP-dependent transcription factor ATF-4
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer
Gene
ATF4
Synonyms
CREB2 TXREB
Protein Name
Cyclic AMP-dependent transcription factor ATF-4
UniProt ID
P18848 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000336790
NCBI Gene ID
468
Molecular Weight
38590
Protein Length
351
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1ci6)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Cell membrane,Nucleus,Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome;
Function
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088).
Gene Ontology
GO:1990590; GO:1990589; GO:1990617; GO:0005737; GO:0032590; GO:1990037; GO:0005815; GO:0043005; GO:0034399; GO:0005654; GO:0005634; GO:0032991; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0043522; GO:0008022; GO:0046982; GO:0019901; GO:0000980; GO:0000978; GO:0000977; GO:0001085; GO:0043565; GO:0044212; GO:0006520; GO:0006874; GO:0034198; GO:1903351; GO:0042149; GO:0090650; GO:0034644; GO:0032922; GO:0007214; GO:0006094; GO:0070059; GO:0042789; GO:0120163; GO:1903204; GO:0043267; GO:0032057; GO:0030182; GO:0036499; GO:0043065; GO:0070169; GO:0010628; GO:0043525; GO:2000120; GO:0045943; GO:0045944; GO:0061395; GO:1990440; GO:0036091; GO:0036003; GO:0045893; GO:1905461; GO:0010575; GO:0006357; GO:0006355; GO:0034976; GO:1990737; GO:0009636; GO:0006366
 
Gene Ontology