Protein Name
Sodium/hydrogen exchanger 1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
90763
Protein Length
815
Protein Domain
3D Structure
(PDB ID : 1y4e)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Membrane,Endoplasmic reticulum membrane,Cell membrane;
Function
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
Gene Ontology
GO:0016324; GO:0016323; GO:0090533; GO:0009986; GO:0005737; GO:0005783; GO:0005789; GO:0070062; GO:0005925; GO:0016021; GO:0005887; GO:0014704; GO:0030027; GO:0045121; GO:0005739; GO:0005654; GO:0048471; GO:0005886; GO:0030315; GO:0048306; GO:0005516; GO:0005546; GO:0015386; GO:0030674; GO:0030346; GO:0032947; GO:0015385; GO:0086040; GO:0015299; GO:0086003; GO:0055007; GO:0016477; GO:0071468; GO:0071236; GO:0070417; GO:0071257; GO:0071872; GO:0071456; GO:0032869; GO:0071260; GO:0006883; GO:0030214; GO:0006811; GO:0030011; GO:0043066; GO:0070997; GO:0045760; GO:0043065; GO:0070886; GO:1903281; GO:0010613; GO:0030307; GO:0035794; GO:0098735; GO:0045944; GO:0071805; GO:0051259; GO:1902600; GO:0086036; GO:0010882; GO:0051893; GO:0051453; GO:0006885; GO:0051930; GO:0051492; GO:0086092; GO:0010447; GO:0035994; GO:0036376; GO:0098719