STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide

Cell membrane,Sarcolemma,Cell projection,Dendritic spine;

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.

GO:0044305; GO:0005901; GO:0005737; GO:0005856; GO:0005829; GO:0043197; GO:0045121; GO:0005739; GO:0005654; GO:0005634; GO:0048471; GO:0001917; GO:0005886; GO:0014069; GO:0032991; GO:0042383; GO:0016529; GO:0033017; GO:0045202; GO:0030315; GO:0012506; GO:0030018; GO:0034618; GO:0046870; GO:0005516; GO:0050660; GO:0010181; GO:0020037; GO:0044325; GO:0050661; GO:0003958; GO:0004517; GO:0016491; GO:0097110; GO:0017080; GO:0034617; GO:0006527; GO:0045454; GO:0071363; GO:0042738; GO:0033555; GO:0007520; GO:0045776; GO:0051926; GO:0010523; GO:0051346; GO:0043267; GO:0051612; GO:0042136; GO:0006809; GO:0007263; GO:0018119; GO:0140196; GO:0031284; GO:0035066; GO:1902307; GO:0098735; GO:0045944; GO:0045893; GO:1902514; GO:1903779; GO:0055117; GO:0050767; GO:0060314; GO:0002028; GO:0009408; GO:0009725; GO:0001666; GO:0032496; GO:0098924; GO:0006941; GO:0042311