ADRA1B | Alpha-1B adrenergic receptor
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
ADRA1B
Synonyms
-
Protein Name
Alpha-1B adrenergic receptor
UniProt ID
P35368 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000306662
NCBI Gene ID
147
Molecular Weight
56836
Protein Length
520
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus membrane,Cell membrane,Cytoplasm,Membrane,Caveola;
Function
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
Gene Ontology
GO:0005901; GO:0005737; GO:0005887; GO:0031965; GO:0005634; GO:0005886; GO:0004935; GO:0004937; GO:0046982; GO:0071880; GO:0007188; GO:0008283; GO:0007267; GO:0007186; GO:0042593; GO:0035556; GO:0007275; GO:0001994; GO:0007200; GO:0007204; GO:0043410; GO:0045987; GO:0045907; GO:0055117
 
Gene Ontology