Protein Name
Pancreas/duodenum homeobox protein 1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
30999
Protein Length
284
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Nucleus,Cytoplasm,Cytosol;
Function
Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'.
Gene Ontology
GO:0005737; GO:0005829; GO:0016607; GO:0005654; GO:0005634; GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:1990841; GO:0046982; GO:0044877; GO:0000978; GO:0043565; GO:0008134; GO:0031100; GO:0010260; GO:0030154; GO:0007417; GO:0051594; GO:0048565; GO:0031018; GO:0031017; GO:0042593; GO:0006006; GO:0030073; GO:0001889; GO:0016331; GO:0008285; GO:1902236; GO:0000122; GO:0045892; GO:2000675; GO:0007263; GO:0031016; GO:0010942; GO:0008284; GO:0043388; GO:0032024; GO:0035774; GO:0045944; GO:0045893; GO:0042127; GO:0010468; GO:0006357; GO:0043279; GO:0010157; GO:0034097; GO:0070542; GO:0051384; GO:0009749; GO:0010040; GO:0043201; GO:0035094; GO:0033273; GO:0009611; GO:0007224; GO:0048863; GO:0006366; GO:0006351; GO:0060290; GO:0003309