CXCR4 | C-X-C chemokine receptor type 4
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
CXCR4
Synonyms
-
Protein Name
C-X-C chemokine receptor type 4
UniProt ID
P61073 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000241393
NCBI Gene ID
7852
Molecular Weight
39746
Protein Length
352
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2k03)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cell membrane,Cell junction,Early endosome,Late endosome,Lysosome;
Function
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:28978524, PubMed:18799424, PubMed:24912431). Involved in the AKT signaling cascade (PubMed:24912431). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524). Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity).(Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:8849450, PubMed:8929542, PubMed:9427609, PubMed:10074122, PubMed:10756055).
Gene Ontology
GO:0030054; GO:0031252; GO:0009986; GO:0005737; GO:0031410; GO:0005769; GO:0009897; GO:0070062; GO:0016021; GO:0005770; GO:0005764; GO:0005886; GO:0032991; GO:0003779; GO:0019957; GO:0016493; GO:0016494; GO:0038147; GO:0019956; GO:0015026; GO:0004930; GO:0032027; GO:0043130; GO:0031625; GO:0001618; GO:0000187; GO:0006915; GO:0007411; GO:0007420; GO:0019722; GO:0060326; GO:0071345; GO:0006935; GO:0038160; GO:0002407; GO:0030260; GO:0019064; GO:0007186; GO:0006955; GO:0006954; GO:0043217; GO:0022008; GO:0120162; GO:0007204; GO:0048714; GO:0050920; GO:0001666; GO:0009615
 
Gene Ontology