Protein Name
ATP-sensitive inward rectifier potassium channel 11
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
43608
Protein Length
390
Protein Domain
3D Structure
(PDB ID : 5twv)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Function
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity).
Gene Ontology
GO:0001669; GO:0030673; GO:0070852; GO:0005829; GO:0005783; GO:0005768; GO:0014704; GO:0043231; GO:0008282; GO:0005739; GO:0043209; GO:0043025; GO:0005635; GO:0005886; GO:0042383; GO:0030315; GO:0030506; GO:0005524; GO:0015272; GO:0031072; GO:0005242; GO:0044325; GO:0008022; GO:0071333; GO:0071316; GO:0071356; GO:0006006; GO:0046676; GO:0050877; GO:2001259; GO:1903078; GO:1990573; GO:0006813; GO:0042391; GO:0033198; GO:0042493; GO:0032355; GO:0002931; GO:0033574