PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
 
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Sequence Viewer
Gene
PLCB3
Synonyms
-
Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
UniProt ID
Q01970 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000279230
NCBI Gene ID
5331
Molecular Weight
138799
Protein Length
1234
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 3ohm)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
3.1.4.11; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)
Localization
Membrane;
Function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Gene Ontology
GO:0005829; GO:0016020; GO:0005654; GO:0099524; GO:0032991; GO:0045296; GO:0005509; GO:0005516; GO:0004435; GO:0004629; GO:0007186; GO:0043647; GO:0032959; GO:0016042; GO:0048015; GO:0003073; GO:0051209; GO:0007223
 
Gene Ontology