Protein Name
Glutamate receptor ionotropic, NMDA 2B
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
166367
Protein Length
1484
Protein Domain
3D Structure
(PDB ID : 1s11)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cell membrane,Cell junction,Synapse,Postsynaptic cell membrane;
Function
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity).
Gene Ontology
GO:0030054; GO:0009986; GO:0005737; GO:0005887; GO:0043005; GO:0017146; GO:0005886; GO:0014069; GO:0098839; GO:0045211; GO:0097060; GO:0001540; GO:0016595; GO:0022849; GO:0016594; GO:0004972; GO:0005088; GO:0008270; GO:0007420; GO:0097553; GO:0007268; GO:0048013; GO:0098976; GO:0060079; GO:0007215; GO:0007611; GO:0060291; GO:0000165; GO:0007275; GO:1902951; GO:2001056; GO:1901216; GO:0051290; GO:0048167; GO:0045471