CaMKinet | Result

Gene

PLD1

Synonyms

Protein Name

Phospholipase D1

UniProt ID

Q13393 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000342793

NCBI Gene ID

5337

Molecular Weight

124184

Protein Length

1074

Protein Domain

InterPro | Pfam

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

3.1.4.4; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)

Localization

Cytoplasm,Perinuclear region,Endoplasmic reticulum membrane,Golgi apparatus membrane,Late endosome membrane;

Function

Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).

Gene Ontology

GO:0016324; GO:0098981; GO:0030139; GO:0005789; GO:0005768; GO:0005794; GO:0000139; GO:0031902; GO:0005765; GO:0016020; GO:0048471; GO:0005886; GO:0035579; GO:0070821; GO:0070290; GO:0035091; GO:0004630; GO:0048870; GO:0006935; GO:0048017; GO:0016042; GO:0043312; GO:0006654; GO:0007265; GO:0032534; GO:0098693; GO:0007264