VPS72 | Vacuolar protein sorting-associated protein 72 homolog
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
VPS72
Synonyms
TCFL1 YL1
Protein Name
Vacuolar protein sorting-associated protein 72 homolog
UniProt ID
Q15906 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000346464
NCBI Gene ID
6944
Molecular Weight
40594
Protein Length
364
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 5fug)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus;
Function
Deposition-and-exchange histone chaperone specific for H2AFZ, specifically chaperones H2AFZ and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AFZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.
Gene Ontology
GO:0016607; GO:0005654; GO:0005634; GO:0032991; GO:0003677; GO:0042393; GO:0043486; GO:0000122; GO:0035019