Protein Name
CREB-regulated transcription coactivator 2
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
73302
Protein Length
693
Protein Domain
3D Structure
(PDB ID : 4htm)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Nucleus;
Function
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Gene Ontology
GO:0005737; GO:0070062; GO:0005654; GO:0005634; GO:0008140; GO:0003682; GO:0006094; GO:0042593; GO:0043970; GO:0032793; GO:0045944; GO:0051289; GO:1901998; GO:0016032