SPHK2 | Sphingosine kinase 2
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer
Gene
SPHK2
Synonyms
-
Protein Name
Sphingosine kinase 2
UniProt ID
Q9NRA0 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000245222
NCBI Gene ID
56848
Molecular Weight
69217
Protein Length
654
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.1.91; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+)
Localization
Isoform 1: Cytoplasm,Membrane;Isoform 2: Lysosome membrane;
Function
Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides.
Gene Ontology
GO:0005829; GO:0043231; GO:0005765; GO:0016020; GO:0005524; GO:0017050; GO:0003951; GO:0017016; GO:0008481; GO:0038036; GO:0001568; GO:0007420; GO:0008283; GO:0007565; GO:0043066; GO:0008284; GO:0006669; GO:0030148; GO:0046512
 
Gene Ontology