CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

STK17B

Synonyms

DRAK2

Protein Name

Serine/threonine-protein kinase 17B

UniProt ID

O94768

Ensembl Gene ID

9606.ENSP00000263955

NCBI Gene ID

9262

Molecular Weight

42,344

Protein Length

372

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 3lm0)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Nucleus Cell membrane Endoplasmic reticulum-Golgi intermediate compartment Note=Colocalizes with STK17B at the plasma membrane.

Function

Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.

Gene Ontology

GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005793; GO:0005886; GO:0006468; GO:0006915; GO:0015629; GO:0035556; GO:0046777; GO:2000271

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
STK17B (O94768)	Homo sapiens	S10	RRRFDCRSISGLLTT	0.609	0.2988	-	-	-	-	-	-	-
STK17B (O94768)	Homo sapiens	S12	RFDCRSISGLLTTTP	0.362	0.2849	-	-	-	-	-	-	-
DAPK1 (P53355)	Homo sapiens	S308	ARKKWKQSVRLISLC	-	0.1048	-	-	-	-	-	-	-
STX1A (Q16623)	Homo sapiens	S188	IIMDSSISKQALSEI	0.028	0.3426	-	-	-	-	-	-	-
CAMKK2 (Q96RR4)	Homo sapiens	S511	RREERSLSAPGNLLT	0.556	0.7916	-	-	-	-	-	-	-
RPS6KB1 (P23443)	Homo sapiens	T412	NQVFLGFTYVAPSVL	0.928	0.2129	-	-	-	-	-	-	-

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found