CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	CAMKK2
Protein Name	KKCC2_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta)
Protein Family	Protein kinase superfamily
NCBI Gene ID	10645
UniProt ID	Q96RR4
Enzyme Class	2.7.11.17
Molecular Weight	64746
Protein Length	588
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a protein = ADP + a phosphoprotein.
Localization	Nucleus
Function (UniProt annotation)	Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
Gene Ontology	GO:0000165; GO:0001934; GO:0004683; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005622; GO:0005634; GO:0005829; GO:0006468; GO:0019722; GO:0034614; GO:0042995; GO:0045859; GO:0045893; GO:0046777; GO:0061762; GO:1903599

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
DAPK1 (P53355)	Homo sapiens	S511	RREERSLSAPGNLLT	0.556	0.7916	TP	certain	-	66 \| 74 \| 30 \| 62 \| 55 \|	15209507	-	-
CAMKK2 (Q96RR4)	Homo sapiens	T85	GQEVPLDTSGSQARP	0.032	0.7951	-	-	-	-	-	-	in-vitro
DAPK3 (O43293)	Homo sapiens	S511	RREERSLSAPGNLLT	0.556	0.7916	-	-	-	-	-	-	-
DAPK2 (Q9UIK4)	Homo sapiens	S511	RREERSLSAPGNLLT	0.556	0.7916	-	-	-	-	-	-	-
STK17B (O94768)	Homo sapiens	S511	RREERSLSAPGNLLT	0.556	0.7916	-	-	-	-	-	-	-
STK17A (Q9UEE5)	Homo sapiens	S511	RREERSLSAPGNLLT	0.556	0.7916	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04920	Adipocytokine signaling pathway

No NCI Nature pathways found