CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	DAPK1
Protein Name	DAPK1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)
Protein Family	Protein kinase superfamily
NCBI Gene ID	1612
UniProt ID	P53355
Enzyme Class	2.7.11.1
Molecular Weight	160046
Protein Length	1430
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a protein = ADP + a phosphoprotein.
Localization	Isoform 1: Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with MAP1B in the microtubules and cortical actin fibers.; Isoform 2: Cytoplasm. Cytoplasm, cytoskeleton.
Function (UniProt annotation)	Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.; Isoform 2 cannot induce apoptosis but can induce membrane blebbing.
Gene Ontology	GO:0004672; GO:0004674; GO:0004683; GO:0005516; GO:0005524; GO:0005525; GO:0005634; GO:0005737; GO:0005886; GO:0006468; GO:0006915; GO:0008625; GO:0010506; GO:0010508; GO:0015629; GO:0017075; GO:0017148; GO:0035556; GO:0042802; GO:0042981; GO:0043066; GO:0043280; GO:0046777; GO:0071346; GO:0071447; GO:0097190; GO:2000310

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
RPS6KA3 (P51812)	Homo sapiens	S289	QALSRKASAVNMEKF	N/A	0.3426	TP	certain	experimental	72 \| 73 \| 140 \| 214 \| 9 \| 55 \|	16213824	-	In vivo
DAPK1 (P53355)	Homo sapiens	S308	ARKKWKQSVRLISLC	N/A	0.1048	TP	certain	-	9 \| 72 \| 73 \|	11579085	-	-
RPS6KA2 (Q15349)	Homo sapiens	S289	QALSRKASAVNMEKF	N/A	0.3426	-	-	-	-	16213824	Non high throughput (16213824)	-
RPS6KA1 (Q15418)	Homo sapiens	S289	QALSRKASAVNMEKF	N/A	0.3426	-	-	-	-	-	-	In vivo
DAPK1 (P53355)	Homo sapiens	S313	KQSVRLISLCQRLSR	N/A	0.0929	-	-	-	-	-	-	-
DAPK3 (O43293)	Homo sapiens	S308	ARKKWKQSVRLISLC	N/A	0.1048	-	-	-	-	-	-	-
DAPK2 (Q9UIK4)	Homo sapiens	S308	ARKKWKQSVRLISLC	N/A	0.1048	-	-	-	-	-	-	-
STK17B (O94768)	Homo sapiens	S308	ARKKWKQSVRLISLC	N/A	0.1048	-	-	-	-	-	-	-
STK17A (Q9UEE5)	Homo sapiens	S308	ARKKWKQSVRLISLC	N/A	0.1048	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa05200	Pathways in cancer
hsa05219	Bladder cancer

NCI Nature PID Pathways

Pathway ID	Pathway Name
ifngpathway	IFN-gamma pathway