CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

PRKD3

Synonyms

EPK2 PRKCN

Protein Name

Serine/threonine-protein kinase D3

UniProt ID

O94806

Ensembl Gene ID

9606.ENSP00000234179

NCBI Gene ID

23683

Molecular Weight

1,00,471

Protein Length

890

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2D9Z)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.13 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Cytoplasm Membrane Note=Translocation to the cell membrane is required for kinase activation.

Function

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity).

Gene Ontology

GO:0004674; GO:0004697; GO:0005524; GO:0005654; GO:0005829; GO:0006468; GO:0007205; GO:0016020; GO:0016301; GO:0030148; GO:0046872; GO:0089700

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKD1 (Q15139)	Homo sapiens	S738	ARIIGEKSFRRSVVG	0.59	0.0851	-	-	-	-	-	-	In vivo
PRKD1 (Q15139)	Homo sapiens	S742	GEKSFRRSVVGTPAY	0.714	0.1373	-	-	-	-	-	-	In vivo
HDAC5 (Q9UQL6)	Homo sapiens	S498	RPLSRTQSSPLPQSP	0.94	0.9168	-	-	-	-	-	-	In vitro
GIT1 (Q9Y2X7)	Homo sapiens	S46	RSLGRHISIVKHLRH	0.866	0.2715	-	-	-	-	-	-	in-vitro and in-vivo
GSK3A (P49840)	Homo sapiens	S21	SGRARTSSFAEPGGG	0	0.923	-	-	-	-	-	-	-
GSK3B (P49841)	Homo sapiens	S9	SGRPRTTSFAESCKP	0.5	0.6043	-	-	-	-	-	-	-
RTKN (Q9BST9)	Homo sapiens	S448	QALAKQGSLYHEMAI	0.952	0.5055	-	-	-	-	-	-	-
SPHK2 (Q9NRA0)	Homo sapiens	S419	AHSPLHRSVSDLPLP	0.402	0.6806	-	-	-	-	-	-	-
SPHK2 (Q9NRA0)	Homo sapiens	S421	SPLHRSVSDLPLPLP	0.657	0.6089	-	-	-	-	-	-	-

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found