| Gene |
GSK3A
|
| Protein Name |
GSK3A_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
2931
|
| UniProt ID |
P49840
|
| Enzyme Class |
2.7.11.26; 2.7.11.1 |
| Molecular Weight |
50981 |
| Protein Length |
483 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + [tau protein] = ADP + [tau protein] phosphate.; ATP + a protein = ADP + a phosphoprotein. |
| Localization |
N/A |
| Function (UniProt annotation) |
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. |
| Gene Ontology |
GO:0003073; GO:0003214; GO:0004674; GO:0005102; GO:0005524; GO:0005739; GO:0005829; GO:0005977; GO:0006468; GO:0007212; GO:0007399; GO:0008286; GO:0010628; GO:0010905; GO:0016055; GO:0018107; GO:0030877; GO:0031398; GO:0032007; GO:0032436; GO:0032869; GO:0034236; GO:0036016; GO:0036498; GO:0043025; GO:0043161; GO:0045719; GO:0045732; GO:0045823; GO:0046325; GO:0046627; GO:0050321; GO:0060079; GO:0061052; GO:0071879; GO:0090090; GO:0097191; GO:0097192; GO:0097440; GO:0098794; GO:0106071; GO:1901030; GO:1902004; GO:1903146; GO:1903955; GO:1904227; GO:1990635; GO:2000077; GO:2000466; GO:2000467 |
