CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	SPHK2
Protein Name	SPHK2_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91)
Protein Family	N/A
NCBI Gene ID	56848
UniProt ID	Q9NRA0
Enzyme Class	2.7.1.91
Molecular Weight	69217
Protein Length	654
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate.
Localization	Isoform 1: Cytoplasm. Membrane.; Isoform 2: Lysosome membrane.
Function (UniProt annotation)	Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides.
Gene Ontology	GO:0001568; GO:0003951; GO:0005524; GO:0005765; GO:0005829; GO:0006669; GO:0007420; GO:0007565; GO:0008283; GO:0008284; GO:0008481; GO:0016020; GO:0017016; GO:0017050; GO:0030148; GO:0038036; GO:0043066; GO:0043231; GO:0046512

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKD1 (Q15139)	Homo sapiens	S419	AHSPLHRSVSDLPLP	0.402	0.6806	-	-	-	-	-	-	In vivo
PRKD1 (Q15139)	Homo sapiens	S421	SPLHRSVSDLPLPLP	0.657	0.6089	-	-	-	-	-	-	In vivo
PRKD3 (O94806)	Homo sapiens	S419	AHSPLHRSVSDLPLP	0.402	0.6806	-	-	-	-	-	-	-
PRKD3 (O94806)	Homo sapiens	S421	SPLHRSVSDLPLPLP	0.657	0.6089	-	-	-	-	-	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa00600	Sphingolipid metabolism
hsa01100	Metabolic pathways
hsa04020	Calcium signaling pathway
hsa04370	VEGF signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis
hsa05152	Tuberculosis

NCI Nature PID Pathways

Pathway ID	Pathway Name
ceramidepathway	Ceramide signaling pathway
il12_2pathway	IL12-mediated signaling events
s1p_meta_pathway	Sphingosine 1-phosphate (S1P) pathway