CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	HDAC5
Protein Name	HDAC5_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)
Protein Family	Histone deacetylase family
NCBI Gene ID	10014
UniProt ID	Q9UQL6
Enzyme Class	3.5.1.98
Molecular Weight	121978
Protein Length	1122
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Localization	Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.
Function (UniProt annotation)	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Gene Ontology	GO:0000118; GO:0000122; GO:0000978; GO:0001085; GO:0003682; GO:0004407; GO:0005080; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0006325; GO:0006338; GO:0006342; GO:0006476; GO:0006954; GO:0008134; GO:0010830; GO:0010832; GO:0014823; GO:0016575; GO:0016607; GO:0030182; GO:0030183; GO:0032041; GO:0032869; GO:0033558; GO:0040029; GO:0042113; GO:0042220; GO:0042826; GO:0043393; GO:0045892; GO:0045944; GO:0046872; GO:0051091; GO:0070491; GO:0071222; GO:0090051

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKD2* (Q9BZL6)	Homo sapiens	S498	RPLSRTQSSPLPQSP	0.94	0.9168	TP	likely	experimental	73 \|	16584705	-	In vitro
MARK2 (Q7KZI7)	Homo sapiens	S259	FPLRKTASEPNLKVR	0.835	0.6806	TP	certain	experimental	72 \| 55 \|	16980613	-	In vivo
CAMK4 (Q16566)	Homo sapiens	S259	FPLRKTASEPNLKVR	0.835	0.6806	TP	certain	experimental	9 \| 143 \|	11081517	-	-
CAMK1 (Q14012)	Homo sapiens	S259	FPLRKTASEPNLKVR	0.835	0.6806	TP	certain	experimental	9 \| 143 \|	11081517	-	-
CAMK4 (Q16566)	Homo sapiens	S498	RPLSRTQSSPLPQSP	0.94	0.9168	TP	certain	experimental	9 \| 143 \|	11081517	-	-
CAMK1 (Q14012)	Homo sapiens	S498	RPLSRTQSSPLPQSP	0.94	0.9168	TP	certain	experimental	9 \| 143 \|	11081517	-	-
SIK3 (M5FMX3)	Homo sapiens	S259	FPLRKTASEPNLKVR	0.835	0.6806	TP	certain	experimental	72 \| 73 \| 74 \| 55 \|	23393134	-	-
SIK2 (Q9H0K1)	Homo sapiens	S259	FPLRKTASEPNLKVR	0.835	0.6806	TP	certain	experimental	72 \| 73 \| 74 \| 55 \|	23393134	-	-
PRKAA1 (Q13131)	Homo sapiens	S259	FPLRKTASEPNLKVR	0.835	0.6806	TP	certain	experimental	9 \| 23 \| 3 \| 72 \| 55 \|	18184930	-	-
PRKAA1 (Q13131)	Homo sapiens	S498	RPLSRTQSSPLPQSP	0.94	0.9168	TP	certain	experimental	9 \| 23 \| 3 \| 72 \| 55 \|	18184930	-	-
PRKD3 (O94806)	Homo sapiens	S498	RPLSRTQSSPLPQSP	0.94	0.9168	-	-	-	-	-	-	In vitro
PRKAA2 (P54646)	Homo sapiens	S259	FPLRKTASEPNLKVR	0.835	0.6806	-	-	-	-	-	-	In vivo
PRKAA2 (P54646)	Homo sapiens	S498	RPLSRTQSSPLPQSP	0.94	0.9168	-	-	-	-	-	-	In vivo
PRKD1 (Q15139)	Homo sapiens	S259	FPLRKTASEPNLKVR	0.835	0.6806	-	-	-	-	-	-	In vivo
PRKD1 (Q15139)	Homo sapiens	S498	RPLSRTQSSPLPQSP	0.94	0.9168	-	-	-	-	-	-	In vitro and in vivo
CAMK2A (Q9UQM7)	Homo sapiens	S259	FPLRKTASEPNLKVR	0.835	0.6806	-	-	-	-	-	-	in-vivo
CAMK2A (Q9UQM7)	Homo sapiens	S498	RPLSRTQSSPLPQSP	0.94	0.9168	-	-	-	-	-	-	in-vivo
SIK1 (P57059)	Homo sapiens	S259	FPLRKTASEPNLKVR	0.835	0.6806	-	-	-	-	-	-	-
SIK1 (P57059)	Homo sapiens	S498	RPLSRTQSSPLPQSP	0.94	0.9168	-	-	-	-	-	-	-
CAMK2D (Q13557)	Homo sapiens	S498	RPLSRTQSSPLPQSP	0.94	0.9168	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

NCI Nature PID Pathways

Pathway ID	Pathway Name
hdac_classi_pathway	Signaling events mediated by HDAC Class I
hdac_classii_pathway	Signaling events mediated by HDAC Class II