CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

MYLK3

Synonyms

MLCK

Protein Name

Myosin light chain kinase 3

UniProt ID

Q32MK0

Ensembl Gene ID

9606.ENSP00000378288

NCBI Gene ID

91807

Molecular Weight

88,393

Protein Length

819

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : N/A)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.18 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.

Localization

Cytoplasm

Function

Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity).

Gene Ontology

GO:0002528; GO:0004683; GO:0004687; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0015629; GO:0045214; GO:0048769; GO:0055003; GO:0060298; GO:0071347

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Ppp1r2 (P50411)	Rattus norvegicus	S44	EEELSKKSQKWDEMN	-	0.5707	-	-	-	-	-	-	in-vivo
PPP1R2B (G1AUC5)	Homo sapiens	S44	DEELSKKSQKWDEIN	-	-	-	-	-	-	-	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04020	Calcium signaling pathway
hsa04270	Vascular smooth muscle contraction
hsa04510	Focal adhesion
hsa04810	Regulation of actin cytoskeleton
hsa04971	Gastric acid secretion

No NCI Nature pathways found