| Gene |
KRT18
|
| Protein Name |
K1C18_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) |
| Protein Family |
Intermediate filament family |
| NCBI Gene ID |
3875
|
| UniProt ID |
P05783
|
| Enzyme Class |
- |
| Molecular Weight |
48058 |
| Protein Length |
430 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm, perinuclear region. Nucleus, nucleolus. |
| Function (UniProt annotation) |
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. |
| Gene Ontology |
GO:0003723; GO:0005198; GO:0005730; GO:0005737; GO:0005815; GO:0005829; GO:0005882; GO:0005913; GO:0007049; GO:0009653; GO:0016032; GO:0031424; GO:0033209; GO:0034451; GO:0043000; GO:0043066; GO:0045095; GO:0045104; GO:0048471; GO:0070062; GO:0070268; GO:0071944; GO:0097110; GO:0097191; GO:0097284; GO:0098641 |
