CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	CRTC2
Protein Name	CRTC2_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2)
Protein Family	TORC family
NCBI Gene ID	200186
UniProt ID	Q53ET0
Enzyme Class	-
Molecular Weight	73302
Protein Length	693
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm
Function (UniProt annotation)	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Gene Ontology	GO:0003682; GO:0005634; GO:0005654; GO:0005737; GO:0006094; GO:0008140; GO:0016032; GO:0032793; GO:0042593; GO:0043970; GO:0045944; GO:0051289; GO:0070062; GO:1901998

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Sik1 (Q60670)	Mus musculus	S171	SALNRTSSDSALHTS	0.886	0.662	TP	certain	experimental	72 \| 9 \|	16817901	-	-
PRKAA2 (P54646)	Homo sapiens	S171	SALNRTSSDSALHTS	0.886	0.662	-	-	-	-	-	-	-
SIK1 (P57059)	Homo sapiens	S171	SALNRTSSDSALHTS	0.886	0.662	-	-	-	-	-	-	-
SIK1 (P57059)	Homo sapiens	S274	PAMNTGGSLPDLTNL	0.739	0.6712	-	-	-	-	-	-	-
SIK1 (P57059)	Homo sapiens	S306	PSLSGGNSTSNLTHT	0.885	0.7547	-	-	-	-	-	-	-
SIK1 (P57059)	Homo sapiens	S348	PSLQSSLSNPNLQAS	0.949	0.7163	-	-	-	-	-	-	-
SIK1 (P57059)	Homo sapiens	S70	RSSHYGGSLPNVNQI	0.754	0.562	-	-	-	-	-	-	-
MARK2 (Q7KZI7)	Homo sapiens	S171	SALNRTSSDSALHTS	0.886	0.662	-	-	-	-	-	-	-
MARK2 (Q7KZI7)	Homo sapiens	S274	PAMNTGGSLPDLTNL	0.739	0.6712	-	-	-	-	-	-	-
SIK2 (Q9H0K1)	Homo sapiens	S171	SALNRTSSDSALHTS	0.886	0.662	-	-	-	-	-	-	-
SIK3 (Q9Y2K2)	Homo sapiens	S171	SALNRTSSDSALHTS	0.886	0.662	-	-	-	-	-	-	-
SIK3 (Q9Y2K2)	Homo sapiens	S348	PSLQSSLSNPNLQAS	0.949	0.7163	-	-	-	-	-	-	-
SIK3 (Q9Y2K2)	Homo sapiens	S70	RSSHYGGSLPNVNQI	0.754	0.562	-	-	-	-	-	-	-
MARK3 (P27448)	Homo sapiens	S274	PAMNTGGSLPDLTNL	0.739	0.6712	-	-	-	-	-	-	-
MARK2 (Q7KZI7)	Homo sapiens	S306	PSLSGGNSTSNLTHT	0.885	0.7547	-	-	-	-	-	-	-
MARK4 (Q96L34)	Homo sapiens	S171	SALNRTSSDSALHTS	0.886	0.662	-	-	-	-	-	-	-
MARK4 (Q96L34)	Homo sapiens	S274	PAMNTGGSLPDLTNL	0.739	0.6712	-	-	-	-	-	-	-
MARK4 (Q96L34)	Homo sapiens	S306	PSLSGGNSTSNLTHT	0.885	0.7547	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found