| Gene |
E2F3
|
| Protein Name |
E2F3_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Transcription factor E2F3 (E2F-3) |
| Protein Family |
E2F/DP family |
| NCBI Gene ID |
1871
|
| UniProt ID |
O00716
|
| Enzyme Class |
- |
| Molecular Weight |
49162 |
| Protein Length |
465 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus. |
| Function (UniProt annotation) |
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity). |
| Gene Ontology |
GO:0000122; GO:0000981; GO:0000987; GO:0001077; GO:0001078; GO:0001228; GO:0003700; GO:0005654; GO:0006367; GO:0007049; GO:0008134; GO:0008284; GO:0043565; GO:0045944; GO:0046983; GO:0051726; GO:0070345; GO:0090575; GO:1905461 |
