CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	MDM4
Protein Name	MDM4_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Protein Family	MDM2/MDM4 family
NCBI Gene ID	4194
UniProt ID	O15151
Enzyme Class	-
Molecular Weight	54864
Protein Length	490
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus.
Function (UniProt annotation)	Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
Gene Ontology	GO:0000122; GO:0005634; GO:0005654; GO:0006977; GO:0008270; GO:0008283; GO:0008285; GO:0016579; GO:0019899; GO:0030330; GO:0042177; GO:0043066; GO:0045023; GO:0050821; GO:0061630; GO:0065003; GO:0071157; GO:0071456; GO:1901796

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Prkaa1 (P54645)	Rattus norvegicus	S342	SKLTHSLSTSDITAI	0.727	0.4369	TP	certain	experimental	72 \| 73 \| 9 \| 30 \| 55 \|	24190973	-	-
CHEK1 (O14757)	Homo sapiens	S342	SKLTHSLSTSDITAI	0.727	0.4369	-	-	-	-	-	-	In vitro
CHEK1 (O14757)	Homo sapiens	S367	PDCRRTISAPVVRPK	0.922	0.4409	-	-	-	-	-	-	In vitro and in vivo
CHEK2 (O96017)	Homo sapiens	S342	SKLTHSLSTSDITAI	0.727	0.4369	-	-	-	-	-	-	In vitro and in vivo
CHEK2 (O96017)	Homo sapiens	S367	PDCRRTISAPVVRPK	0.922	0.4409	-	-	-	-	-	-	In vitro and in vivo

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04115	p53 signaling pathway

No NCI Nature pathways found