| Gene |
TP73
|
| Protein Name |
P73_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Tumor protein p73 (p53-like transcription factor) (p53-related protein) |
| Protein Family |
P53 family |
| NCBI Gene ID |
7161
|
| UniProt ID |
O15350
|
| Enzyme Class |
- |
| Molecular Weight |
69623 |
| Protein Length |
636 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage. |
| Function (UniProt annotation) |
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. |
| Gene Ontology |
GO:0000187; GO:0000785; GO:0000978; GO:0000981; GO:0001077; GO:0001822; GO:0002039; GO:0003700; GO:0005634; GO:0005654; GO:0005739; GO:0005794; GO:0005829; GO:0006298; GO:0006974; GO:0007050; GO:0007346; GO:0008134; GO:0008285; GO:0008630; GO:0010243; GO:0010468; GO:0016032; GO:0019901; GO:0030054; GO:0042493; GO:0042771; GO:0042802; GO:0042981; GO:0043231; GO:0044212; GO:0045665; GO:0045893; GO:0045944; GO:0046872; GO:0048714; GO:0051262; GO:0060044; GO:0071158; GO:0097371; GO:1900740; GO:1901796; GO:1902036 |
