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Parameter | Value |
---|---|
Gene | SPRY2 |
Protein Name | SPY2_HUMAN |
Organism | Homo sapiens (Human) |
Alternative name(s) | Protein sprouty homolog 2 (Spry-2) |
Protein Family | Sprouty family |
NCBI Gene ID | 10253 |
UniProt ID | O43597 |
Enzyme Class | - |
Molecular Weight | 34688 |
Protein Length | 315 |
Protein Domain | InterPro | Pfam |
3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase | SwissModel |
Gene Expression | Gene Expression Atlas |
Function and Disease | OMIM |
Protein-protein Interaction Database | STRING | IntAct | MINT |
Kinase Database | Phospho.ELM | PhosphoSite | NetworKIN |
Catalytic Activity (UniProt annotation) | - |
Localization | Cytoplasm, cytoskeleton Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor). |
Function (UniProt annotation) | May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. |
Gene Ontology | GO:0000132; GO:0005634; GO:0005829; GO:0005856; GO:0005874; GO:0005886; GO:0007605; GO:0008285; GO:0010628; GO:0010801; GO:0015630; GO:0016020; GO:0016525; GO:0019901; GO:0030291; GO:0030335; GO:0031345; GO:0032587; GO:0033138; GO:0034260; GO:0035924; GO:0040037; GO:0042059; GO:0042472; GO:0043066; GO:0043407; GO:0043539; GO:0045165; GO:0045595; GO:0046580; GO:0051387; GO:0051897; GO:0060437; GO:0060449; GO:0070373; GO:0070374; GO:1900747; GO:1990830 |
Gene Name | Organism | P-Site | Sequence(+/-7) | Conservation | Disorder | Curator Assessment | Reliability | Evidence Class | Evidence Logic | PubMed | Phospho-ELM | PhosphoSite-Plus |
---|---|---|---|---|---|---|---|---|---|---|---|---|
MKNK2 (Q9HBH9) | Homo sapiens | S112 | APLSRSISTVSSGSR | 0.354 | 0.712 | TP | certain | experimental | 140 | 148 | 8 | | 19864419 | - |
|
MKNK2 (Q9HBH9) | Homo sapiens | S121 | VSSGSRSSTRTSTSS | 0.854 | 0.7369 | TP | certain | experimental | 140 | 148 | 8 | | 19864419 | - |
|
MKNK1 (Q9BUB5) | Homo sapiens | S112 | APLSRSISTVSSGSR | 0.354 | 0.712 | TP | certain | experimental | 107 | 147 | 73 | 72 | 62 | 148 | | 16479008 | - |
|
MKNK1 (Q9BUB5) | Homo sapiens | S121 | VSSGSRSSTRTSTSS | 0.854 | 0.7369 | TP | certain | experimental | 107 | 147 | 73 | 72 | 62 | 148 | | 16479008 | - |
|
Reactome Pathways
KEGG Pathways
Pathway ID | Pathway Name |
---|---|
hsa04630 | Jak-STAT signaling pathway |
No NCI Nature pathways found