| Gene |
ERBB2
|
| Protein Name |
ERBB2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
2064
|
| UniProt ID |
P04626
|
| Enzyme Class |
2.7.10.1 |
| Molecular Weight |
137910 |
| Protein Length |
1255 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Localization |
Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.; Isoform 2: Cytoplasm. Nucleus.; Isoform 3: Cytoplasm. Nucleus. |
| Function (UniProt annotation) |
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. |
| Gene Ontology |
GO:0000165; GO:0001042; GO:0001934; GO:0004713; GO:0004714; GO:0004888; GO:0005088; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005887; GO:0006357; GO:0006468; GO:0007165; GO:0007166; GO:0007167; GO:0007169; GO:0007422; GO:0007507; GO:0007528; GO:0008022; GO:0008045; GO:0008283; GO:0009925; GO:0009968; GO:0010008; GO:0014065; GO:0016021; GO:0016323; GO:0016324; GO:0019903; GO:0030154; GO:0030307; GO:0032886; GO:0033088; GO:0038128; GO:0042060; GO:0042552; GO:0042802; GO:0043066; GO:0043125; GO:0043209; GO:0043235; GO:0043406; GO:0043547; GO:0045727; GO:0045765; GO:0045785; GO:0045943; GO:0045945; GO:0046777; GO:0046934; GO:0046982; GO:0046983; GO:0048471; GO:0048709; GO:0050679; GO:0051897; GO:0070372; GO:0070374; GO:0071363; GO:0071364; GO:0090314; GO:1901185; GO:2000145 |
