CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	ETS1
Protein Name	ETS1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Protein C-ets-1 (p54)
Protein Family	ETS family
NCBI Gene ID	2113
UniProt ID	P14921
Enzyme Class	-
Molecular Weight	50408
Protein Length	441
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm
Function (UniProt annotation)	Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
Gene Ontology	GO:0000978; GO:0000981; GO:0000982; GO:0001077; GO:0001666; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0006357; GO:0006366; GO:0006955; GO:0007565; GO:0008134; GO:0008284; GO:0008285; GO:0009612; GO:0010595; GO:0010628; GO:0010715; GO:0021854; GO:0021983; GO:0030154; GO:0030578; GO:0032355; GO:0034616; GO:0035035; GO:0042802; GO:0042981; GO:0043536; GO:0044849; GO:0045648; GO:0045765; GO:0045766; GO:0045786; GO:0045893; GO:0045944; GO:0046677; GO:0048870; GO:0050728; GO:0050729; GO:0051272; GO:0060055; GO:0061614; GO:0070301; GO:0070555; GO:1904996

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	S251	GKLGGQDSFESIESY	0.994	0.4087	-	-	-	-	12475968	Non high throughput (12475968)	In vitro and in vivo
CAMK2A (Q9UQM7)	Homo sapiens	S257	DSFESIESYDSCDRL	0.404	0.4369	-	-	-	-	12475968	Non high throughput (12475968)	In vitro and in vivo
CAMK2A (Q9UQM7)	Homo sapiens	S282	NSLQRVPSYDSFDSE	0.369	0.3774	-	-	-	-	12475968	Non high throughput (12475968)	In vitro and in vivo
CAMK2A (Q9UQM7)	Homo sapiens	S285	QRVPSYDSFDSEDYP	0.381	0.3774	-	-	-	-	12475968	Non high throughput (12475968)	In vitro and in vivo

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04320	Dorso-ventral axis formation
hsa05200	Pathways in cancer
hsa05211	Renal cell carcinoma

NCI Nature PID Pathways

Pathway ID	Pathway Name
angiopoietinreceptor_pathway	Angiopoietin receptor Tie2-mediated signaling
bcr_5pathway	BCR signaling pathway
hif1_tfpathway	HIF-1-alpha transcription factor network
il4_2pathway	IL4-mediated signaling events