CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	CEBPB
Protein Name	CEBPB_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5)
Protein Family	BZIP family
NCBI Gene ID	1051
UniProt ID	P17676
Enzyme Class	-
Molecular Weight	36106
Protein Length	345
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus
Function (UniProt annotation)	Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity).
Gene Ontology	GO:0000122; GO:0000779; GO:0000790; GO:0000977; GO:0000978; GO:0000979; GO:0000981; GO:0001077; GO:0001078; GO:0001541; GO:0001892; GO:0002432; GO:0003677; GO:0003682; GO:0003700; GO:0003705; GO:0005634; GO:0005654; GO:0005737; GO:0006355; GO:0006366; GO:0006953; GO:0006954; GO:0006955; GO:0007613; GO:0016363; GO:0019900; GO:0030182; GO:0032753; GO:0033598; GO:0034976; GO:0035035; GO:0035259; GO:0035711; GO:0036488; GO:0042130; GO:0042742; GO:0042803; GO:0042826; GO:0043524; GO:0044389; GO:0045408; GO:0045600; GO:0045669; GO:0045670; GO:0045893; GO:0045944; GO:0046982; GO:0050873; GO:0060644; GO:0060850; GO:0070059; GO:0070169; GO:0071222; GO:0071230; GO:0071347; GO:0071407; GO:0072574; GO:0097421; GO:0120162; GO:1901329; GO:1990440; GO:2000120

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
RPS6KA1 (Q15418)	Homo sapiens	T266	VKSKAKKTVDKHSDE	0.154	0.6851	-	-	-	-	10635333	Non high throughput (10635333)	-
CAMK2A (Q9UQM7)	Homo sapiens	S325	EQLSRELSTLRNLFK	0.002	0.5382	-	-	-	-	-	-	-
CAMK2B (Q13554)	Homo sapiens	S325	EQLSRELSTLRNLFK	0.002	0.5382	-	-	-	-	-	-	-
CAMK2D (Q13557)	Homo sapiens	S325	EQLSRELSTLRNLFK	0.002	0.5382	-	-	-	-	-	-	-
CAMK2G (Q13555)	Homo sapiens	S325	EQLSRELSTLRNLFK	0.002	0.5382	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa05152	Tuberculosis

NCI Nature PID Pathways

Pathway ID	Pathway Name
hnf3apathway	FOXA1 transcription factor network
hnf3bpathway	FOXA2 and FOXA3 transcription factor networks
ifngpathway	IFN-gamma pathway
il4_2pathway	IL4-mediated signaling events
il6_7pathway	IL6-mediated signaling events
p38alphabetadownstreampathway	Signaling mediated by p38-alpha and p38-beta
smad2_3nuclearpathway	Regulation of nuclear SMAD2/3 signaling