| Gene |
ATF4
|
| Protein Name |
ATF4_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (DNA-binding protein TAXREB67) (Tax-responsive enhancer element-binding protein 67) (TaxREB67) |
| Protein Family |
BZIP family |
| NCBI Gene ID |
468
|
| UniProt ID |
P18848
|
| Enzyme Class |
- |
| Molecular Weight |
38590 |
| Protein Length |
351 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088). |
| Gene Ontology |
GO:0000977; GO:0000978; GO:0000980; GO:0000981; GO:0001077; GO:0001085; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0005815; GO:0006094; GO:0006355; GO:0006357; GO:0006366; GO:0006520; GO:0006874; GO:0007214; GO:0008022; GO:0009636; GO:0010575; GO:0010628; GO:0019901; GO:0030182; GO:0032057; GO:0032590; GO:0032922; GO:0032991; GO:0034198; GO:0034399; GO:0034644; GO:0034976; GO:0036003; GO:0036091; GO:0036499; GO:0042149; GO:0042789; GO:0043005; GO:0043065; GO:0043267; GO:0043522; GO:0043525; GO:0043565; GO:0044212; GO:0045893; GO:0045943; GO:0045944; GO:0046982; GO:0061395; GO:0070059; GO:0070169; GO:0090650; GO:0120163; GO:1903204; GO:1903351; GO:1905461; GO:1990037; GO:1990440; GO:1990589; GO:1990590; GO:1990617; GO:1990737; GO:2000120 |
