KEGG pathway - MAPK signaling pathway

CaM Kinases known in this pathway:

Name	Synonyms	EntryName	Phosphorylate Substrates
MAPKAPK2	MAP kinase-activated protein kinase 2	P49137	TH \| EEF2K \| TP53 \| KRT18 \| TH \| TH \| VIM \| SRF \| Hspb1 \| Lsp1 \| Zfp36 \| LSP1 \| Ddit3 \| VIM \| MAPKAPK2 \| MDM2 \| RCSD1 \| Hnrnpa0 \| Krt20 \| HSPB1 \| TSC2 \| BAG2 \| ALOX5 \| YWHAZ \| ARPC5 \| CDC25B \| HSF1 \| LIMK1 \| AKT1 \| PLK1 \| ZFP36L1 \| Etv1 \| RTN4 \| TRIM29 \| PIAS1 \| AATF \| AGO2 \| PARN \| CRYAB \| Creb1 \| CREB1 \| Rps6ka1 \| ATF1 \| SHC1 \| CDC25B \| CDC25C \| KRT20 \| Pde4a \| Creb1 \| BCL2L1 \| HNRNPA0 \| Lpcat2 \| Gys1 \| Rps6ka3 \| WNK4 \| Rbm7 \| MRTFA \| Ripk1 \| TH \| Mrtfa \| CEP131 \| DDX5 \| DAZL \| RIPK1 \| Hif3a \| TRIM28 \| PFKFB3 \| BECN1 \| ZFP36 \| PDE4A \| LSP1 \| ETV1 \| RPS6KA3 \| E2F1 \| RPS6KA1 \| LPCAT2 \| TAB3 \| MYLK2 \| RPS6KA1 \| ZFP36 \| DDIT3 \| \| \| RBM7 \| RIPK1 \| PDE4A \|
MAPKAPK3	MAP kinase-activated protein kinase 3	Q16644	RCSD1 \| TCF3 \| RTN4 \| RTN4 \| BECN1 \| EEF2K \| HSPB1 \| KRT20 \| TAB3 \|
MKNK1	MAP kinase-interacting serine/threonine-protein kinase 1	Q9BUB5	Eif4e \| SPRY2 \| SFPQ \| HNRNPA1 \| EIF4E \| Pla2g4a \| PNPLA8 \| PLA2G4A \| \| EIF4E \|
MKNK2	MAP kinase-interacting serine/threonine-protein kinase 2	Q9HBH9	SPRY2 \| SFPQ \| PLEC \| EIF4E \| HNRNPA1 \| ADRB2 \| CHRM2 \| MC4R \| CCR5 \| ADRA1B \|
RPS6KA1	Ribosomal protein S6 kinase alpha-1	Q15418	EEF2K \| MITF \| FOS \| ESR1 \| Nr4a1 \| ITGB4 \| CREB1 \| SLC9A1 \| FLNA \| EIF4B \| NFKBIA \| L1CAM \| IRS1 \| TSC2 \| Tsc2 \| GSK3B \| ETV1 \| DAPK1 \| RPS6 \| YBX1 \| CCT2 \| MDM2 \| MXD1 \| Mitf \| RPS6KA1 \| NFKBIB \| PPP1R3A \| Bad \| Kcnd3 \| Rps6ka1 \| Dlc1 \| Eif4b \| RPTOR \| DEPTOR \| ESR2 \| BAD \| CIC \| RANBP3 \| Krt17 \| METTL1 \| NDRG2 \| CARHSP1 \| Nos1 \| Cebpb \| CEBPB \| CDKN1B \| VASP \| GMFB \| Cebpb \| UBR5 \| Mapk7 \| MAPK7 \| WWC1 \| Gab2 \| CDC25C \| CHEK1 \| PDCD4 \| SOS1 \| LCP1 \| APAF1 \| Senp2 \| OSTF1 \| CDC25A \| EPHA2 \| CDC25B \| SLC9A3R1 \| CDC34 \| SENP2 \|
RPS6KA2	Ribosomal protein S6 kinase alpha-2	Q15349	FOS \| CREB1 \| ATF4 \| DAPK1 \| MEF2C \| Atf4 \| NFATC4 \| BAD \| RRN3 \| CDKN1B \| RPS6KA2 \|
RPS6KA3	Ribosomal protein S6 kinase alpha-3	P51812	KCNK3 \| ESR1 \| EIF2S1 \| Nr4a1 \| Htr2a \| Creb1 \| ATF4 \| EIF2AK2 \| Cebpb \| NFKBIA \| HIST1H2BB \| STAT3 \| Gata4 \| CDKN1B \| GSK3A \| GSK3B \| DAPK1 \| Mybpc3 \| RPS6 \| YBX1 \| PPP1R3A \| NFATC4 \| RRN3 \| HMGN1 \| TH \| TH \| TH \| CREB1 \| PFKFB2 \| Mybpc3 \| Rps6 \| HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J \| H3F3A; H3F3B \| PPP1R3A \| BAD \| CIC \| RANBP3 \| MAP3K5 \| WWC1 \| TH \| TINF2 \| LCP1 \| TBX21 \| FGFR1 \| STMN1 \| EPHA2 \| SLC9A3 \| CASP8 \|
RPS6KA4	Ribosomal protein S6 kinase alpha-4	O75676	CREB1 \| RELA \| RPS6KA4 \| Hist1h3a; Hist1h3g; Hist1h3h; Hist1h3i \|
RPS6KA5	Ribosomal protein S6 kinase alpha-5	O75582	RPS6KA5 \| HMGN1 \| TH \| HIST1H2AG; HIST1H2AI; HIST1H2AK; HIST1H2AL; HIST1H2AM \| SRF \| Nr4a1 \| Creb1 \| CREB1 \| ATF1 \| ELK1 \| PLA2G4A \| HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J \| Hist1h3a; Hist1h3g; Hist1h3h; Hist1h3i \| H3F3A; H3F3B \| RELA \| Rela \| Eif4ebp1 \| Bad \| WNK1 \| Hist1h2ad \| Hist1h2ab \| RARA \| ATXN1 \| Trim28 \|
RPS6KA6	Ribosomal protein S6 kinase alpha-6	Q9UK32
MAPKAPK5	MAP kinase-activated protein kinase 5	Q8IW41	SEPT8; \| SEPT8; \| DNAJB1 \| FOXO3 \| TP53 \| HSPB1 \| TH \| PLA2G4A \| KALRN \| DNAJB1 \| RHEB \| EEF2K \|

Substrates known in this pathway:

Name	Protein Names	EntryName	Phosphorylated by CaM kinases
AKT1	RAC-alpha serine/threonine-protein kinase	P31749	MAPKAPK2 \| SIK2 \| PRKD1 \| CAMKK2 \|
ATF4	Cyclic AMP-dependent transcription factor ATF-4	P18848	RPS6KA3 \| RPS6KA2 \|
CACNA1C	Voltage-dependent L-type calcium channel subunit alpha-1C	Q13936	PRKD1 \| CAMK2A \|
CACNB2	Voltage-dependent L-type calcium channel subunit beta-2	Q08289
CDC25B	M-phase inducer phosphatase 2	P30305	MELK \| MAPKAPK2 \| BRSK1 \| CHEK1 \| RPS6KA1 \|
EGFR	Epidermal growth factor receptor	P00533	PRKD1 \| CAMK2A \| PRKAA1 \|
ELK1	ETS domain-containing protein Elk-1	P19419	RPS6KA5 \|
FLNA	Filamin-A	P21333	RPS6KA1 \| CAMK2A \| CAMK2B \| CAMK2D \| CAMK2G \|
FOS	Proto-oncogene c-Fos	P01100	RPS6KA2 \| RPS6KA1 \|
HSPB1	Heat shock protein beta-1	P04792	MAPKAPK2 \| PRKD1 \| MAPKAPK5 \| MAPKAPK3 \| CAMK1 \| CAMK4 \|
IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta	O14920	PRKAA2 \|
JUN	Transcription factor AP-1	P05412	PRKD1 \|
MAP3K5	Mitogen-activated protein kinase kinase kinase 5	Q99683	PIM1 \| Melk \| RPS6KA3 \| PRKD1 \| MELK \|
MAP4K1	Mitogen-activated protein kinase kinase kinase kinase 1	Q92918	PRKD1 \|
MAPKAPK2	MAP kinase-activated protein kinase 2	P49137	MAPKAPK2 \|
MAPT	Microtubule-associated protein tau	P10636	SIK1 \| PRKAA1 \| BRSK2 \| BRSK1 \| MARK4 \| MARK1 \|
MEF2C	Myocyte-specific enhancer factor 2C	Q06413	RPS6KA2 \| MYLK2 \|
NFATC4	Nuclear factor of activated T-cells, cytoplasmic 4	Q14934	RPS6KA3 \| RPS6KA2 \|
NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEK1 \|
PAK1	Serine/threonine-protein kinase PAK 1	Q13153	BRSK2 \| STK11 \|
PAK2	Serine/threonine-protein kinase PAK 2	Q13177
PLA2G4A	Cytosolic phospholipase A2	P47712	RPS6KA5 \| MAPKAPK5 \| CAMK2A \| MKNK1 \|
RELA	Transcription factor p65	Q04206	PIM1 \| CAMK2G \| RPS6KA4 \| RPS6KA5 \| CAMK4 \| CHEK1 \|
RPS6KA1	Ribosomal protein S6 kinase alpha-1	Q15418	RPS6KA1 \| MAPKAPK2 \|
RPS6KA4	Ribosomal protein S6 kinase alpha-4	O75676	RPS6KA4 \|
RPS6KA5	Ribosomal protein S6 kinase alpha-5	O75582	RPS6KA5 \|
SRF	Serum response factor	P11831	MAPKAPK2 \| CAMK4 \| RPS6KA5 \| CAMK2A \|
STMN1	Stathmin	P16949	CAMK4 \| CAMK2B \| CAMK2A \| RPS6KA3 \|
TP53	Cellular tumor antigen p53	P04637	DAPK1 \| MAPKAPK2 \| STK11 \| NUAK1 \| MAPKAPK5 \| STK17A \| CHEK1 \| DAPK3 \| CHEK2 \| PRKAA1 \| SIK1 \| MELK \| PRKAA2 \|
CDC25B	M-phase inducer phosphatase 2	P30305	MELK \| MAPKAPK2 \| BRSK1 \| CHEK1 \| RPS6KA1 \|