CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	CDC25A
Protein Name	MPIP1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A)
Protein Family	MPI phosphatase family
NCBI Gene ID	993
UniProt ID	P30304
Enzyme Class	3.1.3.48
Molecular Weight	59087
Protein Length	524
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Localization	N/A
Function (UniProt annotation)	Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
Gene Ontology	GO:0000079; GO:0000082; GO:0000086; GO:0004721; GO:0004725; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0008283; GO:0009314; GO:0010971; GO:0016579; GO:0019901; GO:0034644; GO:0045931; GO:0051087; GO:0051301; GO:0051726; GO:0110032

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CHEK1 (O14757)	Homo sapiens	S76	SNLQRMGSSESTDSG	0.668	0.5807	TP	certain	experimental	72 \| 107 \| 73 \| 9 \|	12759351	-	-
CHEK1 (O14757)	Homo sapiens	S124	PALKRSHSDSLDHDI	0.462	0.4541	TP	certain	experimental	72 \| 107 \| 9 \|	12759351	-	-
CHEK1 (O14757)	Homo sapiens	S178	LFTQRQNSAPARMLS	0.959	0.6851	TP	certain	experimental	72 \| 107 \| 9 \|	12759351	-	-
CHEK1 (O14757)	Homo sapiens	S279	VLKRPERSQEESPPG	0.549	0.892	-	-	-	-	12676583	Non high throughput (12676583)	In vitro and in vivo
CHEK1 (O14757)	Homo sapiens	S293	GSTKRRKSMSGASPK	0.631	0.8765	-	-	-	-	12676583	Non high throughput (12676583)	In vitro and in vivo
CHEK2 (O96017)	Homo sapiens	S124	PALKRSHSDSLDHDI	0.462	0.4541	-	-	-	-	11298456	Non high throughput (11298456)	In vitro and in vivo
CHEK2 (O96017)	Homo sapiens	S178	LFTQRQNSAPARMLS	0.959	0.6851	-	-	-	-	12676583	Non high throughput (12676583)	In vitro
CHEK2 (O96017)	Homo sapiens	S279	VLKRPERSQEESPPG	0.549	0.892	-	-	-	-	12676583	Non high throughput (12676583)	In vitro
CHEK2 (O96017)	Homo sapiens	S293	GSTKRRKSMSGASPK	0.631	0.8765	-	-	-	-	12676583	Non high throughput (12676583)	In vitro
PIM1 (P11309)	Homo sapiens	S116	PQKLLGCSPALKRSH	0.618	0.5533	-	-	-	-	12411508	Non high throughput (12411508)	-
CHEK1 (O14757)	Homo sapiens	T507	KFRTKSRTWAGEKSK	0.183	0.4017	-	-	-	-	14559997	Non high throughput (14559997)	In vitro and in vivo
RPS6KA1 (Q15418)	Homo sapiens	S295	TKRRKSMSGASPKES	0.296	0.8853	-	-	-	-	-	-	in-vitro and in-vivo
RPS6KA1 (Q15418)	Homo sapiens	S293	GSTKRRKSMSGASPK	0.631	0.8765	-	-	-	-	-	-	in-vitro and in-vivo
CHEK1 (O14757)	Homo sapiens	S107	NPMRRIHSLPQKLLG	0.691	0.5456	-	-	-	-	-	-	-
CHEK1 (O14757)	Homo sapiens	S298	RKSMSGASPKESTNP	0.371	0.8462	-	-	-	-	-	-	-
CHEK2 (O96017)	Homo sapiens	S298	RKSMSGASPKESTNP	0.371	0.8462	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04110	Cell cycle
hsa04914	Progesterone-mediated oocyte maturation

No NCI Nature pathways found