CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J
Protein Name	H31_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Protein Family	Histone H3 family
NCBI Gene ID	8.35E+39
UniProt ID	P68431
Enzyme Class	-
Molecular Weight	15404
Protein Length	136
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus. Chromosome.
Function (UniProt annotation)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Gene Ontology	GO:0000183; GO:0000228; GO:0000786; GO:0000788; GO:0005576; GO:0005634; GO:0005654; GO:0006325; GO:0006334; GO:0006335; GO:0007596; GO:0016020; GO:0031492; GO:0032200; GO:0032991; GO:0038111; GO:0044267; GO:0045296; GO:0045652; GO:0045814; GO:0046982; GO:0051290; GO:0060964; GO:0060968; GO:0070062

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PIM1 (P11309)	Homo sapiens	S11	TKQTARKSTGGKAPR	0.711	0.7595	TP	certain	experimental	72 \| 73 \| 55 \| 23 \| 9 \|	17643117	-	-
RPS6KA5 (O75582)	Homo sapiens	S11	TKQTARKSTGGKAPR	0.711	0.7595	-	-	-	-	-	-	In vitro and in vivo
RPS6KA5 (O75582)	Homo sapiens	S29	ATKAARKSAPATGGV	0.614	0.6482	-	-	-	-	-	-	In vitro and in vivo
RPS6KA3 (P51812)	Homo sapiens	S11	TKQTARKSTGGKAPR	0.711	0.7595	-	-	-	-	-	-	In vivo
DAPK3 (O43293)	Homo sapiens	T12	KQTARKSTGGKAPRK	0.62	0.7505	-	-	-	-	12560483	Non high throughput (12560483)	-
CHEK1 (O14757)	Homo sapiens	T12	KQTARKSTGGKAPRK	0.62	0.7505	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa05322	Systemic lupus erythematosus
hsa05322	Systemic lupus erythematosus
hsa05322	Systemic lupus erythematosus
hsa05322	Systemic lupus erythematosus
hsa05322	Systemic lupus erythematosus
hsa05322	Systemic lupus erythematosus
hsa05322	Systemic lupus erythematosus
hsa05322	Systemic lupus erythematosus
hsa05322	Systemic lupus erythematosus
hsa05322	Systemic lupus erythematosus

No NCI Nature pathways found