| Gene |
PLCB3
|
| Protein Name |
PLCB3_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) |
| Protein Family |
N/A |
| NCBI Gene ID |
5331
|
| UniProt ID |
Q01970
|
| Enzyme Class |
3.1.4.11 |
| Molecular Weight |
138799 |
| Protein Length |
1234 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
1-phosphatidyl-1D-myo-inositol 4 |
| Localization |
Membrane; Peripheral membrane protein. |
| Function (UniProt annotation) |
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. |
| Gene Ontology |
GO:0003073; GO:0004435; GO:0004629; GO:0005509; GO:0005516; GO:0005654; GO:0005829; GO:0007186; GO:0007223; GO:0016020; GO:0016042; GO:0032991; GO:0035556; GO:0043647; GO:0045296; GO:0099524 |
