| Gene |
SMAD4
|
| Protein Name |
SMAD4_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4) |
| Protein Family |
Dwarfin/SMAD family |
| NCBI Gene ID |
4089
|
| UniProt ID |
Q13485
|
| Enzyme Class |
- |
| Molecular Weight |
60439 |
| Protein Length |
552 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling (PubMed:25514493). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |
| Gene Ontology |
GO:0000122; GO:0000790; GO:0000978; GO:0000981; GO:0000987; GO:0001077; GO:0001085; GO:0001541; GO:0001658; GO:0001666; GO:0001701; GO:0001702; GO:0003148; GO:0003190; GO:0003198; GO:0003220; GO:0003251; GO:0003360; GO:0003682; GO:0003712; GO:0005518; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005813; GO:0005829; GO:0006879; GO:0007179; GO:0007183; GO:0007283; GO:0007338; GO:0007411; GO:0007492; GO:0007498; GO:0008283; GO:0008285; GO:0010614; GO:0010718; GO:0010862; GO:0014033; GO:0016579; GO:0017015; GO:0030308; GO:0030509; GO:0030511; GO:0030513; GO:0030616; GO:0032444; GO:0032525; GO:0032909; GO:0033686; GO:0035019; GO:0035556; GO:0036302; GO:0042118; GO:0042733; GO:0042802; GO:0042803; GO:0043199; GO:0044212; GO:0045892; GO:0045893; GO:0045944; GO:0046872; GO:0046881; GO:0046982; GO:0048589; GO:0048663; GO:0048733; GO:0048859; GO:0051098; GO:0051571; GO:0051797; GO:0060065; GO:0060391; GO:0060395; GO:0060412; GO:0060548; GO:0060956; GO:0061040; GO:0061614; GO:0062009; GO:0070102; GO:0070207; GO:0070373; GO:0070411; GO:0070412; GO:0071141; GO:0071559; GO:0071773; GO:0072133; GO:0072134; GO:0072520; GO:1901522; GO:1905305; GO:2000617 |
