CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	NFATC4
Protein Name	NFAC4_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3)
Protein Family	N/A
NCBI Gene ID	4776
UniProt ID	Q14934
Enzyme Class	-
Molecular Weight	95449
Protein Length	902
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Function (UniProt annotation)	Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.
Gene Ontology	GO:0000978; GO:0000981; GO:0001078; GO:0001227; GO:0001569; GO:0001816; GO:0003682; GO:0003700; GO:0003713; GO:0005634; GO:0005667; GO:0005829; GO:0006366; GO:0006954; GO:0007507; GO:0008134; GO:0008630; GO:0016607; GO:0030178; GO:0032091; GO:0032760; GO:0033173; GO:0034644; GO:0035562; GO:0042975; GO:0044798; GO:0045333; GO:0045944; GO:0048167; GO:0050774; GO:0051145; GO:0055001; GO:0071285; GO:1902894; GO:1904637; GO:2000297; GO:2001235

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
RPS6KA3 (P51812)	Homo sapiens	S281	SGTPSSASPALSRRG	0.875	0.7369	TP	certain	experimental	74 \| 54 \| 73 \| 8 \| 55 \| 72 \|	17213202	-	In vitro and in vivo
RPS6KA3 (P51812)	Homo sapiens	S285	SSASPALSRRGSLGE	0.879	0.8741	TP	certain	experimental	74 \| 54 \| 73 \| 8 \| 55 \| 72 \|	17213202	-	In vitro and in vivo
RPS6KA3 (P51812)	Homo sapiens	S289	PALSRRGSLGEEGSE	0.901	0.9057	TP	certain	experimental	74 \| 54 \| 73 \| 8 \| 55 \| 72 \|	17213202	-	In vitro and in vivo
RPS6KA3 (P51812)	Homo sapiens	S344	QAVALPRSEEPASCN	0.155	0.7415	TP	certain	experimental	74 \| 54 \| 73 \| 8 \| 55 \| 72 \|	17213202	-	In vitro and in vivo
RPS6KA3 (P51812)	Homo sapiens	S676	SNGRRKRSPTQSFRF	0.769	0.3356	TP	certain	experimental	23 \| 73 \| 9 \| 72 \| 55 \|	15657420	-	In vitro and in vivo
RPS6KA2 (Q15349)	Homo sapiens	S676	SNGRRKRSPTQSFRF	0.769	0.3356	-	-	-	-	15657420	Non high throughput (15657420)	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04010	MAPK signaling pathway
hsa04310	Wnt signaling pathway
hsa04360	Axon guidance
hsa04370	VEGF signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway

No NCI Nature pathways found